The BRIO Study
What is BRIO?
We are recruiting volunteers now
Our previous studies have shown that a compound called sulforaphane, which is found naturally in broccoli, may protect against osteoarthritis.
To determine whether eating broccoli (soup) can improve pain and function symptoms in people with osteoarthritis.
The University of East Anglia and our partners the University of Leeds and the NHS National Institute for Health Research. We have two study centres in the United Kingdom, one in Norwich and one in Leeds.
Osteoarthritis is the most common form of joint disease and affects at least 8 million people in the United Kingdom. This pilot study is a multi-centre, randomised, placebo-controlled, double-blind dietary intervention designed to look at whether broccoli can affect pain in patients with knee osteoarthritis. This means that participants will be randomly assigned to consume the control soup or broccoli soup. Nobody will know which group the participants are assigned until after the trial has finished. This pilot study is crucial for the design and implementation of a full-scale trial that may benefit millions of people.
The study is a collaboration between the University of East Anglia and Leeds University.
Postal Adress: BRIO Research Team, Biomedical Research Centre, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR4 7TJ, United Kingdom
Phone: +44(0) 1603 591471
Always stay updated
This study examines the impact of sulforaphane treatment on signalling pathways in human articular chondrocytes from the knee and demonstrates that sulforaphane might prevent cartilage destruction in osteoarthritis.read more
by Green et al.
Dietary modification could be effective in preventing osteoarthritis. This review focuses on dietary factors that may reduce the risk or progression of OA, including micronutrients, fatty acids, flavonoids and other phytochemicals.read more
There is an unmet need for investment in clinical trials of dietary intervention, for developing disease biomarkers and refining the definition of OA so that clinically relevant outcome measures can be improved.read more
The detection of broccoli-derived natural compounds in the human knee joint following consumption of steamed broccoli and how these may change the protein profile of synovial fluid.read more
This study explored the personal impact of osteoarthritis in a sample of 2000 people in the UK: most reported persistent pain despite medication; the economic and social impact was large; and a need for improvement was identified in the provision of information and promotion of self-management strategies by clinicians to support people in managing their condition.read more
This paper outlines the study protocol for the PROMOTE trial which aims to understand whether methotrexate, the most commonly used drug for treating rheumatoid arthritis, is effective at reducing pain and symptoms of osteoarthritis. The study has recently completed and results will be published shortly.read more
This large UK trial found that hydroxychloroquine was not more effective than placebo in reducing symptoms in people with moderate to severe hand osteoarthritis, providing evidence for a change in practice for the off-label use of this drug in these patients.read more
Chair of Chronic Diseases and Genetic Epidemiology (UEA)
Chair of Musculoskeletal Biology
Chair of Musculoskeletal Medicine
Osteoarthritis Strategic Lead
Professor of Nutrition
Senior Lecturer in Medical Statistics
Chair of Medicine